Apoptosis

Apoptosis Phagocytosis Phosphatidyl serine (PS) normally on the inner leaflet of the plasma tissue layer flips to the outer leaflet Engulfing phagocyte PS receptor (CDI4?) DOCK I80 (CED5 homolog) *CD36 Croquemort (drosophila) Contains SH3 creation which allows interaction with signaling pathways principle of cytoskeleton and stall motility ? *Adhesion molecules which clog TSP and signal via tyrosine kinases Mitochondria Bax Pro-apoptotic Bcl-2 family members promote, and anti-apoptotic Bcl-2 family members deflect mitochondrial cytochrome c release The Bcl-2 Family C Ligand ( tumour necrosis factor) (trimer, cutaneous senses residues in red) N tumor necrosis factor TNF receptor (TNFR) (monomer, cysteines in yellow, contact residues in red) TNF-family death receptors FasL TRAIL TRAIL Anti-apoptotic Bcl-2, Bcl-x L, Mcl-I Bcl-w, A-I BH4 BH4 BH3 BH3 BHI BHI BH2 BH2 TM TM TNFR Fas TRAIL-RI TRAIL-R2 Cytochrome c TSP, macrophage secre ted glycoprotein which provides a bridge between the macrophage and an apoptotic cubicle Exposure of sugar residues on cell-surface carbohydrates Pro-apoptotic Apoptosome Apaf-I Caspase-9 tetramer Procaspase-9 Bcl-x L blocks?

Bik, Hrk, Bim, Blk Bad, Bid BH3 BH3 TM Death effector theater Death domain TNF Tumor necrosis factor TRAIL TNF-related apoptosis-inducing ligand TRADD TNF-receptor-associated death domain FADD Fas-associated death domain TRAF TNFR-associated factor IAP Inhibitor of apoptosis protein Caspases3,6,7 Bax, Bak, Mtd/Bok Bcl-x S BH4 BH3 BHI BH2 TM Death domain TRAF- I TRAF-2 c-IAP Inhibits TNFinduced apoptosis FADD TRADD Recruits and permits caspase-8 transactivat! ion Recruits and permits caspase-8 transactivation FADD Thrombospondin (TSP) moiety PS? *?vB3 Ion flux ATP CDI4 Plasma membrane-bound glycoprotein which binds lipid molecules ABC conveyer (CED7 homolog) utilisation in phagocytosis unclear BH4 BH3 TM ? Unknown adapter recruits and permits caspase-8 transactivation Apoptotic cell Lectins...If you want to get a full essay, fix it on our website: BestEssayCheap.com

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